Non-Small Cell Lung Cancer (NSCLC) in Vulnerable and Special Populations: Towards Personalized Care - PubMed
10 hours ago
- #Personalized Oncology
- #Health Disparities
- #NSCLC
- NSCLC affects diverse populations, including AYA, women, pregnant patients, those with genetic variants, immunocompromised individuals, older adults, brain metastasis patients, and survivors with second primary lung cancers, who are often underrepresented in research.
- Underrepresentation limits generalizable evidence, hindering equitable precision oncology and creating disparities in diagnostic access, trial eligibility, and supportive care.
- Disease biology and treatment responses vary due to factors like genomic differences, age- and sex-related pharmacology, and psychosocial or ethical considerations.
- Advances in molecular testing, targeted therapies, immunotherapy, and antibody-drug conjugates offer new options, but need dedicated safety and efficacy studies in special populations.
- The review emphasizes the need for inclusive research design, clinical practice adaptations, and addressing structural inequities to improve outcomes for all NSCLC patients.