Effect of Direct-from-blood Bacterial Testing on Antibiotics Administration in Adults Presenting With Acute Infection: A Randomized Trial - PubMed
2 hours ago
- #Direct-from-blood testing
- #Pragmatic trial
- #Antibiotic stewardship
- Direct-from-blood bacterial testing significantly reduced the time to obtain test results compared to blood cultures alone (median 0.4 days vs. 5.5 days).
- Despite faster results, the testing did not shorten the duration of intravenous vancomycin or antipseudomonal beta-lactam antibiotic use in adults with suspected infection.
- The study found no significant difference in clinical outcomes between the intervention group with direct-from-blood testing and the usual care group.
- This randomized trial suggests that faster diagnostics alone may not be sufficient to drive earlier antibiotic de-escalation in emergency department settings.