Modulation of PKCα/ETS1 by klotho restores CYB5R4-dependent mitochondrial function in proximal tubular epithelial cells to attenuate the progression of diabetic kidney disease - PubMed
3 hours ago
- #Diabetic Kidney Disease
- #Mitochondrial Function
- #Klotho
- Klotho modulates PKCα/ETS1 to restore CYB5R4-dependent mitochondrial function in proximal tubular epithelial cells.
- This restoration attenuates the progression of diabetic kidney disease.
- The study highlights CYB5R4, ETS1, and mitochondrial function as key elements in PTECs.
- Funding sources include Key Technologies Research and Development Program, National Natural Science Foundation of China, and Chongqing Science and Technology Commission.