Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biom
4 hours ago
- #COPD-CHD comorbidity
- #inflammatory biomarkers
- #sleep patterns
- Study examines the joint associations of sleep patterns and genetic susceptibility with dynamic transitions of COPD and CHD.
- Healthy sleep patterns are linked to lower risks of transitioning from COPD to comorbid CHD and from CHD to comorbid COPD.
- Participants with high genetic risk and poor sleep patterns have the highest risk of comorbidity between COPD and CHD.
- Inflammatory biomarkers like C-reactive protein and glycoprotein acetyls mediate the associations between sleep patterns and comorbidity.
- The study suggests that healthy sleep patterns play a crucial role in mitigating the dynamic transitions of COPD and CHD, partially through inflammatory pathways.