The conserved human astrovirus-receptor interface reveals a targetable vulnerability for antiviral development - PubMed
7 hours ago
- #antiviral therapy
- #FcRn receptor
- #Human astrovirus
- Human astrovirus (HAstV) causes viral enteritis in children and older adults globally.
- Eight serotypes of HAstV (HAstV1-8) use the neonatal Fc receptor (FcRn) as an entry receptor.
- Crystal structure of HAstV8 spike protein complexed with human FcRn reveals a conserved binding interface.
- The binding site overlaps with clinically approved FcRn blockers used for autoimmune diseases.
- FcRn inhibitors effectively suppress astrovirus infection, reducing viral RNA levels in Caco2 cells.
- Study suggests repurposing existing therapeutics to treat astrovirus infections.