TLR7 signature of tumour innervation reveals two distinct pathways of triple-negative breast cancer progression - PubMed
4 hours ago
- #TLR7 signaling
- #tumor innervation
- #TNBC progression
- TLR7 signature scores are higher in triple-negative breast cancer (TNBC) than in ER-positive disease.
- Within TNBC, high TLR7 signaling is linked to basal- and mesenchymal-like subtypes, unlike the luminal androgen receptor (LAR) subtype.
- Both high and low TLR7 scores correlate with poor patient survival compared to intermediate scores across multiple cohorts.
- High TLR7-score tumors show increased cell proliferation, neural pathways, mast cell activity, RB1/TP53 loss, and elevated E2F/PI3K/MET/MYC signaling.
- Low TLR7-score tumors exhibit enhanced ER signaling and T cell pathways, indicating non-innervated TNBC phenotypes.
- TLR7 score is associated with pathological complete response (pCR) in a treatment-dependent manner.
- Findings suggest dual TLR7-dependent and independent progression pathways in TNBC, enabling patient stratification for therapy.