Valproic acid effects on stress-induced depression-like behavior in rodent models: a systematic review and meta-analysis - PubMed
3 hours ago
- #depression
- #Valproic acid
- #meta-analysis
- Valproic acid (VPA) shows antidepressant-like effects in rodent models of stress-induced depression.
- Meta-analysis of 16 experiments using the Forced Swimming Test (FST) found VPA significantly reduced immobility (SMD = -0.93; p = 0.012).
- VPA at 300 mg/kg/day for four weeks notably decreased depressive symptoms.
- Open Field Test (OFT) results indicated VPA increased movement scores in both vertical and horizontal tests.
- Sucrose Preference Test (SPT) showed VPA significantly increased sucrose water consumption.
- No significant effect of VPA was found in the Novel Object Recognition (NOR) test.
- Heterogeneity and potential publication bias suggest cautious interpretation of results.