GSTO1 Promotes Cell Proliferation and Stemness of Cervical Cancer via Activating PI3K/AKT/mTOR Pathway - PubMed
4 hours ago
- #GSTO1
- #PI3K-AKT-mTOR
- #cervical-cancer
- GSTO1 is overexpressed in cervical cancer tissues and associated with poor patient prognosis.
- Knockdown of GSTO1 inhibits cervical cancer cell proliferation, migration, invasion, stemness, and EMT in vitro and reduces tumor growth in vivo.
- GSTO1 knockdown increases reactive oxygen species (ROS) production in cervical cancer cells.
- Transcriptome sequencing reveals that GSTO1 activates the PI3K/AKT signaling pathway, with silencing leading to reduced phosphorylation of PI3K, AKT, and mTOR proteins.
- The PI3K activator 740 Y-P reverses the inhibitory effects of GSTO1 knockdown on cell proliferation, cycle, stemness, and EMT via the PI3K/AKT/mTOR pathway.
- GSTO1 promotes cervical cancer progression through the PI3K/AKT/mTOR pathway, suggesting it as a potential therapeutic target.