Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication - PubMed
2 days ago
- #coronavirus
- #autophagy
- #viral replication
- Coronavirus Nsp3 hijacks CLTC (clathrin heavy chain) to modulate autophagosome nucleation.
- CLTC is essential for DMV (double-membrane vesicle) formation in diverse coronaviruses.
- A live-cell imaging system was developed to visualize DMV formation in real-time during coronavirus infection.
- CLTC interacts with nonstructural protein 3 (nsp3) and maintains the core class III PI3K complex for autophagosome nucleation.
- The study identifies CLTC and the autophagosome nucleation pathway as potential antiviral targets.