Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Mediated Ferritinophagy Through Dual Antioxidant and Anti-Inflammatory Effects - PubMed
4 hours ago
- #IVDD
- #Ferritinophagy
- #Resveratrol
- Resveratrol alleviates intervertebral disc degeneration (IVDD) by targeting NCOA4-mediated ferritinophagy.
- IVDD involves inflammation, cell death, and matrix dysregulation, with ferroptosis and autophagy interactions.
- Multi-omics analysis identified 10 ferroptosis-related hub genes, including NCOA4, TP53, and SLC7A11.
- Single-cell profiling showed dynamic shifts in nucleus pulposus cell (NPCs) phenotypes during degeneration.
- NCOA4-mediated ferritinophagy promotes iron overload and lipid peroxidation, exacerbating oxidative damage.
- Resveratrol mitigates IVDD by restoring disc height, suppressing pro-inflammatory cytokines, and reversing ferroptosis/autophagy imbalance.
- Resveratrol attenuates LPS-induced NPCs degeneration by blocking NCOA4-dependent ferritinophagy.
- NCOA4 is a critical nexus coordinating ferroptosis-autophagy crosstalk in IVDD.
- Resveratrol's therapeutic efficacy involves multi-target modulation of inflammatory and iron homeostasis pathways.