Chemokine-defined macrophage niches establish spatial organization of tumor immunity - PubMed
4 hours ago
- #chemokines
- #macrophages
- #tumor immunity
- Macrophages play a crucial role in tumor immunity, with distinct subsets like CD206hi and CD206lo interstitial macrophages (IMs) and Ly6c2+Fn1+Vcan+ recruited macrophages (recMacs) in lung cancer.
- Chemokine-expressing IM subsets have opposing functions: Cxcl13+CD206hi, Cxcl9+CD206hi, and Cxcl10+CD206hi IMs promote tertiary lymphoid structure formation and lymphocyte recruitment, while Ccl2+ IMs recruit protumorigenic recMacs.
- Ly6C+CD11b+ monocyte-derived dendritic cells (moDCs) act as immunosuppressive antigen-presenting cells in tumor-draining lymph nodes.
- CCR5 blockade with maraviroc during neoantigen vaccination inhibits moDC migration, enhancing dendritic cell-mediated antitumor immunity.
- The study highlights the importance of macrophage lineage and spatial organization in tumor immunity and suggests strategies to enhance protective IM functions while disrupting immunosuppressive mechanisms.