DKK1 expression associates with tertiary lymphoid structure maturity in non-small cell lung cancer - PubMed
8 hours ago
- #DKK1
- #Tertiary lymphoid structures
- #Non-small cell lung cancer
- Tertiary lymphoid structures (TLS) are linked to better prognosis and stronger antitumor immune responses in non-small cell lung cancer (NSCLC).
- A TLS risk score signature (TLSRS) was developed and validated, separating patients into high- and low-risk groups with independent prognostic value.
- DKK1 expression is associated with worse overall survival and negatively correlated with TLS maturity, suggesting it may inhibit TLS maturation in NSCLC.