A multicomponent Fc-fused subunit vaccine induces cross-protective immunity against porcine reproductive and respiratory syndrome virus QYYZ-like and NADC30-like strains - PubMed
4 hours ago
- #Cross-protection
- #Subunit Vaccine
- #PRRSV
- A multicomponent Fc-fused subunit vaccine was developed to combat PRRSV.
- The vaccine targets QYYZ-like and NADC30-like PRRSV strains.
- GP4Fc, GP5Fc, and MFc fusion proteins were expressed using the CHO cell system.
- The vaccine induced both humoral and cellular immune responses in piglets.
- Challenge tests showed reduced viral loads and lung lesions in vaccinated piglets.
- The study suggests Fc-fused subunit vaccines are promising for PRRSV control.