Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling - PubMed
3 hours ago
- #Malaria Prevention
- #Iron Deficiency
- #Plasmodium Infection
- Iron deficiency is associated with a 50% reduction in P. falciparum parasitemia in pregnant women.
- Iron-deficient mice showed improved survival against P. berghei and protection from cerebral malaria.
- Iron chelation alters the transcriptomic and proteomic profile of cultured P. falciparum parasites.
- Intravenous iron supplementation does not increase parasitemia when combined with malaria prevention.
- Findings support WHO recommendations for iron supplementation in malaria-endemic regions with adequate prevention.