Depression of tryptophan may contribute to adverse effects of naproxen - PubMed
6 days ago
- #inflammation
- #tryptophan
- #NSAIDs
- Naproxen, a traditional NSAID, decreases tryptophan and kynurenine levels in plasma.
- Tryptophan depression by naproxen is independent of cyclooxygenase inhibition and occurs due to displacement of bound tryptophan.
- Tryptophan supplementation in naproxen-treated mice reduces fecal blood loss and inflammatory gene expression in the heart.
- Tryptophan also mitigates inflammation and tissue damage-related gene changes in the gut.
- The study suggests tryptophan as a potential biomarker for early detection of NSAID-induced gastrointestinal or cardiovascular effects.