Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT - PubMed
7 hours ago
- #psoriasis
- #mesenchymal stem cells
- #serine metabolism
- Mesenchymal stem cells (MSCs) reduce skin lesions and inflammatory factors in psoriasis models, improving the condition.
- MSCs enhance serine metabolism and upregulate the enzyme PSPH, which is key for their therapeutic effects on psoriasis.
- PSPH promotes mitochondrial autophagy via the PINK1-Parkin pathway and inhibits NLRP3 inflammasome activation, reducing inflammation.