Global molecular landscape of early MASLD progression in human obesity - PubMed
4 hours ago
- #obesity
- #liver fibrosis
- #MASLD
- Study focuses on early-stage Metabolic dysfunction-associated steatotic liver disease (MASLD) in morbidly obese individuals.
- Transcriptomic and metabolomic analyses were performed on liver and plasma samples.
- Plasma metabolomic profile did not fully reflect liver histological features.
- Dual-omics integration revealed significant remodeling in lipid and amino acid metabolism pathways.
- Integrative network analysis identified metabolic remodeling and gene expression as independent features of hepatic steatosis and fibrosis progression.
- GTPases and their regulators were identified as novel genes linked to early liver fibrosis.
- The study provides a detailed molecular landscape of early MASLD and highlights potential targets for obesity-linked liver fibrosis.