Tissue Claudin 18.2 levels as a prognostic factor in gastric adenocarcinomas: A retrospective cohort study - PubMed
4 hours ago
- #gastric adenocarcinoma
- #Claudin 18.2
- #prognostic biomarker
- CLDN18.2 levels are significantly elevated in gastric adenocarcinoma tissues compared to normal tissue and healthy controls.
- High CLDN18.2 levels correlate with Helicobacter pylori infection, poor tumor differentiation, and metastasis, increasing metastasis risk 4.82-fold per 1 ng/mL rise.
- CLDN18.2 shows strong diagnostic performance for gastric adenocarcinoma with 92.4% sensitivity and 100% specificity at a cutoff of 1.675 ng/mL.
- Cox regression analysis identifies CLDN18.2 as an independent prognostic factor for survival outcomes in gastric adenocarcinoma patients.