The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity - PubMed
5 hours ago
- #transcription factors
- #neuroscience
- #developmental biology
- The Fd4 transcription factor translates transient spatial cues into long-term lineage identity in neural progenitors.
- Fd4 is exclusively expressed in a single neuroblast (NB7-1) and its progeny, maintaining lineage-specific neuron production.
- Fd4 is required for the expression of terminal selector genes that define neuronal identity.
- Misexpression of Fd4 can redirect other progenitors to produce NB7-1 lineage-specific neurons.
- Fd4 acts as a 'lineage identity gene', bridging transient spatial signals to long-term cellular memory.
- The findings have potential implications for regenerative therapies targeting neuron replacement.