Antimicrobial resistance dynamics in Mycobacterium tuberculosis coinfection systems: A spatiotemporal strain analysis - PubMed
4 hours ago
- #Mycobacterium tuberculosis
- #Pulmonary infections
- #Antimicrobial resistance
- Secondary pulmonary infections significantly worsen clinical outcomes in pulmonary tuberculosis patients.
- Study focuses on bacterial pathogens and antimicrobial resistance in Yangzhou, China (2021-2024).
- 514 pathogenic bacteria strains identified, 97.08% Gram-negative, primarily Klebsiella pneumoniae (40.27%) and Pseudomonas aeruginosa (15.18%).
- K. pneumoniae shows significant resistance to multiple antibiotics including doxycycline, ceftazidime, and levofloxacin.
- P. aeruginosa resistance to cefazolin and ciprofloxacin is statistically significant.
- Urban vs. rural resistance differences noted, e.g., K. pneumoniae to minocycline in urban areas.
- ESBL-producing K. pneumoniae resistant strains increase annually, with higher rates in rural areas.
- New carbapenem-resistant K. pneumoniae strains emerged in 2023, requiring monitoring.
- Findings support optimizing antibiotic treatment strategies to mitigate resistant strain transmission.