Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders - PubMed
4 hours ago
- #Blood-Brain Barrier
- #Neurodegeneration
- #Aging
- The blood-brain barrier (BBB) maintains CNS homeostasis and regulates immune cell entry.
- Aging leads to BBB degradation through tight junction downregulation, pericyte loss, and other structural changes.
- Altered BBB permeability causes dysregulated immune cell entry, leading to neuroinflammation and neurodegeneration.
- These changes contribute to diseases like Alzheimer's, Parkinson's, and vascular dementia.
- Potential interventions include repairing tight junctions, restoring pericyte function, and modulating immune responses.
- Early diagnosis and targeted therapies could mitigate CNS disorders.