CELF1 is a non-canonical eIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs - PubMed
3 hours ago
- #CELF1
- #eIF4E
- #EMT
- CELF1 is a non-canonical eIF4E binding protein that promotes translation of EMT effector mRNAs.
- CELF1 binds to eIF4E and PABPC1 to enable eIF4G1-independent translation of GRE-containing mRNAs in mesenchymal cells.
- Disruption of the CELF1/eIF4E interaction inhibits EMT induction in vitro and experimental metastasis in vivo.
- The study reveals a novel mode of translational regulation affecting cellular de-differentiation.