Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming - PubMed
3 days ago
- #Epigenetics
- #Nephrology
- #Kidney Development
- Lysine-specific histone demethylase 1a (KDM1A) plays a critical role in nephron development and long-term renal function.
- Depletion of Kdm1a in nephron progenitor cells leads to reduced kidney size in neonates and causes glomerulosclerosis, proteinuria, and renal cysts in adults.
- Kdm1a deletion in podocytes or tubular cells does not replicate the adverse effects seen in nephron progenitor cells.
- CRISPR/Cas9-mediated KDM1A deletion in human kidney organoids results in cyst formation and altered gene expression, including downregulation of podocyte genes and upregulation of metabolic genes.
- Noncoding RNAs associated with KDM1A deletion suggest roles in cell proliferation.
- The study highlights Kdm1a's impact on transcriptional programming and susceptibility to cyst formation, linking it to chronic kidney disease risks.