Unveiling the cellular and molecular mechanisms of traditional Chinese medicine in hepatic fibrosis - PubMed
3 hours ago
- #Systems Pharmacology
- #Traditional Chinese Medicine
- #Hepatic Fibrosis Mechanisms
- TCM addresses hepatic fibrosis (HF) via multi-target regulation of inflammation, oxidative stress, cell death, metabolism, and immune remodeling, rather than single-target inhibition.
- Mechanistically, TCM modulates key pathways like NF-κB, NLRP3, Nrf2, TGF-β/Smad, PI3K/Akt/mTOR, and Wnt/β-catenin to disrupt profibrotic feedback loops.
- Future research should integrate systems approaches (e.g., gut-liver axis, single-cell omics) and long-term clinical studies to validate TCM's system-level antifibrotic effects.