Dynamic polysaccharide-based organic nanocomposite hydrogel precisely mediates oral targeted therapy for colorectal cancer - PubMed
3 hours ago
- #Nanocomposite Hydrogel
- #Oral Drug Delivery
- #Colorectal Cancer
- Dynamic polysaccharide-based organic nanocomposite hydrogel developed for oral targeted therapy of colorectal cancer (CRC).
- Hydrogel fabricated by incorporating lipophilic orthoester (OE)/carboxymethyl chitosan (CMCS)-based nano-prodrugs (NPs) into a gellan gum (GG) matrix.
- GG protects OE/NPs from gastric acid degradation and enables pH-triggered release in the small intestine and colon.
- OE promotes efficient release of NPs via phase separation and hydrolysis, restoring original particle size.
- NPs enhance intestinal absorption, targeted accumulation, and selective cytotoxicity at CRC sites through dynamic size changes.
- The hydrogel alters gut microbiota composition, advancing potential clinical applications.