Mitochondrial function meets oncology: the multifaceted role of TFAM across cancer types - PubMed
8 hours ago
- #Mitochondrial function
- #Therapeutic strategy
- #Cancer biology
- Mitochondrial transcription factor A (TFAM) is crucial for mitochondrial DNA (mtDNA) maintenance and transcription.
- TFAM has a complex and paradoxical role in cancer biology, influencing tumorigenesis in various ways.
- The study uses pan-cancer bioinformatics and experimental evidence to explore TFAM's impact on metabolic reprogramming, signal transduction, and immune microenvironment remodeling.
- TFAM acts as a critical node linking mitochondrial integrity to tumor progression, with context-dependent tumor-promoting or tumor-suppressive roles.
- Challenges in targeting TFAM include off-target toxicity, with emerging strategies like mitochondria-targeted delivery systems being explored.