Functional Ultrasound Imaging-Based Mapping of Cocaine Induced Neural Changes in Awake Mice - PubMed
4 hours ago
- #neuroscience
- #addiction
- #machine-learning
- Cocaine is a commonly used addictive drug with significant medical consequences.
- The study used functional ultrasound imaging (fUS) to map neural changes in awake mice after cocaine exposure.
- Cerebral blood volume (CBV) was measured as an indicator of neuronal activity.
- Acute cocaine exposure increased cortical CBV, indicating heightened neuronal activation.
- Functional connectivity (FC) between the cortex, hippocampus, and thalamus was significantly reduced.
- A Support Vector Machine (SVM) classifier successfully distinguished between baseline and cocaine-exposed states using FC patterns.
- The study highlights the potential of combining neuroimaging and AI for understanding substance use disorders.
- Future research should explore chronic exposure models and include both sexes for better translational relevance.