Defining remission and relapse after allogeneic hematopoietic cell transplantation in myelodysplastic/myeloproliferative neoplasms and optimization of transplantation outcomes: Recommendations from th
10 hours ago
- #EBMT guidelines
- #allogeneic transplantation
- #MDS/MPN neoplasms
- EBMT guidelines define remission and relapse criteria post-allo-HCT for MDS/MPN neoplasms (excluding CMML).
- Recommendations include timing/thresholds for morphological, molecular, cytogenetic, and chimerism analysis to standardize assessment.
- Management strategies for poor graft function and splenomegaly align with those for myelofibrosis and related disorders.
- Relapse after transplantation is common; collaborative clinical trials are needed due to limited evidence.
- The document aims to harmonize post-transplant care, guide research, and address unresolved questions in these rare malignancies.