Alkaline mineral complex water protects piglets against viral infection by driving cholesterol consumption through the GPAT2/SULT2A1 axis - PubMed
3 hours ago
- #lipid metabolism
- #piglet health
- #antiviral
- Alkaline mineral complex (AMC) water protects piglets against viral infections by promoting cholesterol metabolism.
- AMC water reduces virus content and repairs the intestinal mucosal barrier in piglets.
- The study used PEDV, PDCoV, PRV, and PCV as model viruses to test AMC water's antiviral effects.
- Transcriptome and metabolome analyses show AMC water regulates lipid metabolism via GPAT2, DGKA, OAT3, FXR, LIPC, and SULT2A1.
- AMC water inhibits cholesterol accumulation and enhances bile acid synthesis, reducing viral infection.
- Knockdown of DGKA and overexpression of SULT2A1 significantly impact the GPAT2/SULT2A1 axis, reducing viral protein expression.
- The study provides a new nutritional approach for antiviral therapy by targeting lipid metabolism.