STAU1-mediated stabilization of ITGB5 enhances FOXP3 transcriptional activity to form a self-reinforcing metastasis circuit in colorectal cancer - PubMed
2 days ago
- #Molecular Mechanism
- #Colorectal Cancer
- #Metastasis
- STAU1 stabilizes ITGB5 mRNA, enhancing colorectal cancer (CRC) metastasis.
- STAU1 is upregulated in CRC, especially in metastatic tissues, and linked to poor patient outcomes.
- Knockdown of STAU1 reduces metastasis, while overexpression promotes it.
- ITGB5 mRNA is a novel target of STAU1, mediating its pro-metastatic effects.
- STAU1 binds to the 3' UTR of ITGB5 mRNA to stabilize it.
- FOXP3 is identified as a downstream effector of ITGB5 in CRC cells.
- STAU1-mediated ITGB5 upregulation increases FOXP3 phosphorylation, enhancing its transcriptional activity.
- A positive feedback loop (STAU1-ITGB5-FOXP3) drives CRC metastasis and is more pronounced in metastatic CRC specimens.
- The STAU1-ITGB5-FOXP3 loop is proposed as a prognostic biomarker and therapeutic target for metastatic CRC.