Long-term use of melatonin to support sleep may have negative health effects
17 days ago
- #melatonin
- #insomnia
- #heart-failure
- Long-term melatonin use (≥1 year) in adults with insomnia is associated with a higher risk of heart failure diagnosis, hospitalization, and death from any cause.
- The study found a 90% higher chance of incident heart failure in melatonin users compared to non-users (4.6% vs. 2.7%).
- Melatonin users were nearly 3.5 times more likely to be hospitalized for heart failure and twice as likely to die from any cause compared to non-users.
- The study raises safety concerns about melatonin supplements, which are widely available but lack long-term cardiovascular safety data.
- Limitations include potential misclassification of over-the-counter melatonin users and lack of data on insomnia severity or psychiatric disorders.
- Researchers emphasize the need for further studies to confirm these findings and assess melatonin's cardiovascular safety.