Drosophila melanogaster miPEP8 regulates cell size through its interaction with ref(2)P/p62 - PubMed
4 hours ago
- #cell size regulation
- #autophagy
- #Drosophila melanogaster
- Drosophila melanogaster miPEP8 regulates cell size via interaction with ref(2)P/p62.
- miPEP8 overexpression in S2 cells reduces cell size, increases G1 phase proportion, and decreases autophagic flux.
- Proteomics shows miPEP8 upregulates ref(2)P/p62, linking it to mTORC1/autophagy pathway.
- A short linear motif (SLiM) in miPEP8 is crucial for its interaction with ref(2)P/p62.
- Mutation of SLiM or RNA interference of ref(2)P/p62 reverses the cell size phenotype.
- In vivo studies confirm miPEP8's role in wing size regulation in Drosophila.