Lactylation of histone H3K18 promotes autophagic gene expression to mitigate immunosuppression in sepsis - PubMed
7 hours ago
- #Autophagy Regulation
- #Sepsis Immunosuppression
- #Histone Lactylation
- Sepsis-induced immunosuppression is linked to autophagy impairment and glycolytic dysfunction.
- Reduced lactate levels and histone H3K18 lactylation (H3K18la) correlate with impaired autophagy and bacterial clearance.
- H3K18la directly regulates the expression of autophagy genes ATG5 and ATG16L1.
- Lactate supplementation restores H3K18la, increases ATG5/ATG16L1 expression, and rescues autophagy and bactericidal function.
- H3K18la serves as a metabolic-epigenetic checkpoint connecting glycolysis to autophagy in sepsis.