Human 3D Cardiac Microtissue Model to Investigate Aldosterone-Induced Fibrosis and Electrical Dysfunction - PubMed
3 hours ago
- #3D microtissue
- #cardiac fibrosis
- #aldosterone
- Study evaluates aldosterone effects on human 3D cardiac microtissues (hMT).
- Aldosterone induces fibrosis and electrical dysfunction in hMT.
- Eplerenone, a mineralocorticoid receptor antagonist, reverses aldosterone-induced effects.
- hMT model useful for studying aldosterone-mediated cardiac damage.
- Findings support benefits of mineralocorticoid receptor antagonist therapy.