Effects of Intraoperative Esketamine-Dexmedetomidine Combination on Postpartum Depressive Symptoms and Neuropsychiatric Events Following Cesarean Delivery: A Randomized Controlled Trial - PubMed
2 days ago
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- #cesarean-section
- The study compared the effects of intraoperative low-dose dexmedetomidine combined with esketamine versus esketamine alone on postpartum depressive symptoms and neuropsychiatric adverse events in cesarean delivery.
- 134 parturients were randomized into two groups: Group DE (dexmedetomidine + esketamine) and Group E (esketamine alone).
- Group DE showed significantly lower Edinburgh Postnatal Depression Scale (EPDS) scores on postpartum day 7 compared to Group E, but no significant difference at day 42.
- Group DE had a lower incidence of neuropsychiatric adverse events, including dizziness, headache, nausea, and tachycardia.
- Maternal satisfaction scores were higher in Group DE compared to Group E.
- The combination of dexmedetomidine and esketamine provided short-term improvement in postpartum depressive symptoms, reduced adverse events, and enhanced maternal satisfaction with a favorable safety profile.