STAT3 Inhibition Ameliorates Cognitive Dysfunction in Type 2 Diabetes Mellitus by Modulating Astrocytes via Nrf2 Pathway Activation - PubMed
3 days ago
- #STAT3
- #cognitive dysfunction
- #Nrf2
- STAT3 inhibition improves cognitive dysfunction in type 2 diabetes by modulating astrocytes via the Nrf2 pathway.
- The study used both pharmacological inhibition (niclosamide) and genetic silencing to target STAT3 in a mouse model of TDACD.
- STAT3 inhibition reduced neuroinflammation, reactive astrogliosis, and neuronal pathology (amyloid-β and phosphorylated Tau accumulation).
- STAT3 inhibition promoted Nrf2 nuclear translocation and expression of antioxidant enzymes, restoring redox balance.
- Nrf2 silencing eliminated the protective effects of STAT3 inhibition, indicating a STAT3-Nrf2 regulatory axis.
- The findings suggest the STAT3-Nrf2 axis as a promising therapeutic target for TDACD.