Ribosomal protection as a linezolid resistance mechanism in Mycobacterium abscessus - PubMed
4 hours ago
- #antibiotic resistance
- #ABC-F proteins
- #Mycobacterium abscessus
- Mycobacterium abscessus is a significant pulmonary pathogen resistant to most first-line antimycobacterial drugs.
- Linezolid, an oxazolidinone antibiotic, shows clinical efficacy in M. abscessus combination therapies despite moderate resistance in patient isolates.
- The mechanisms of linezolid resistance in M. abscessus are poorly understood.
- ABC-F proteins, such as MAB_2736c in M. abscessus, confer resistance to ribosome-targeting antibiotics like linezolid, macrolides, and chloramphenicol.
- Targeting ABC-F proteins could help combat intrinsic resistance to ribosome-targeting antibiotics in mycobacteria.