HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung - PubMed
4 days ago
- #CD4+ T cells
- #immune network
- #HIF-1α
- HIF-1α+ CD4+ T cells play a key role in coordinating tissue-resident immune cell networks in the lung.
- HIF-1α regulatory activity is higher in lung CD4+ T cells compared to lymph node CD4+ T cells during influenza infection.
- Deletion of Hif1a in CD4+ T cells reduces the tissue-resident T cell compartment without significantly affecting peripheral immunity.
- HIF-1α-active CD4+ T cells are located at the borders of tertiary lymphoid structures and coordinate an IL-21-dependent network of immune cells including macrophages, NK cells, and IgA+ B cells.
- A similar HIF-1α-dependent immune network is observed in lung adenocarcinoma, indicating a broader role in protective immunity during infection and cancer.