Multi-omics Mendelian randomization prioritizes BMP6 as a candidate therapeutic target in intervertebral disc degeneration - PubMed
4 hours ago
- #BMP6
- #Mendelian randomization
- #Intervertebral disc degeneration
- Intervertebral disc degeneration (IVDD) causes significant pain and functional impairment, with limited current treatments.
- Mendelian randomization (MR) was used to identify genetic targets for IVDD using data from FinnGen and UK Biobank.
- Seven potential therapeutic targets were identified, with BMP6 showing strong evidence as a candidate.
- BMP6 was validated at transcriptomic and proteomic levels, significantly increasing IVDD risk (OR = 1.19).
- Urate levels showed a suggestive mediation signal linking BMP6 to IVDD (7.48% mediated).
- BMP6 and urate metabolism are promising targets for IVDD intervention and future research.