Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains - PubMed
3 hours ago
- #gene duplication
- #TRPM evolution
- #metazoan phylogeny
- The TRPM channel family in metazoans experienced multiple gene and domain gains and losses during evolution, with eight members in mammals.
- Four ancestral TRPM genes (α, β, βlike, γ) emerged before bilaterians, with TRPS as a sister channel; mollusks retain all, while other lineages show differential losses.
- Early chordates lost TRPS, TRPMβlike, and TRPMγ, leaving vertebrate ancestors with TRPMα and β, followed by duplications including the 1R tetraploidization.
- Insertion of the mir-211/mir-204 ancestor occurred in a TRPM1/TRPM3 intron, and TRPM6/7 gained a kinase domain from ALPK2/3, adding functional diversity.
- Vertebrate genome duplications (1R, 2R) and local events produced eight TRPMs (TRPM1-8) in gnathostomes; cyclostomes retain four post-hexaploidization, and teleosts expanded via 3R.
- The NUDT9 homology domain is conserved in TRPM2 and TRPS but frequently lost in other TRPMs, highlighting evolutionary variability in domain retention.