NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap formation and lung damage in chronic obstructive pulmonary disease - PubMed
a day ago
- #NCX1
- #Neutrophil Extracellular Traps
- #COPD
- NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap (NET) formation in COPD.
- NCX1 upregulation in neutrophils is linked to cigarette smoke exposure and elevated intracellular Ca²⁺ levels.
- Genetic deletion or pharmacological inhibition of NCX1 suppresses Ca²⁺ influx, NET release, and neutrophil accumulation, improving COPD symptoms.
- Targeting NCX1-mediated Ca²⁺ influx or NET formation is a potential therapeutic strategy for COPD.