In ovo carvacrol enriched inflammatory and T-cell transcriptional responses to Escherichia coli LPS in broiler chickens - PubMed
3 hours ago
- #broiler chickens
- #immunomodulation
- #transcriptomics
- The study investigates the immunomodulatory effects of in ovo carvacrol delivery on broiler chickens' response to E. coli LPS.
- Carvacrol, a phenolic compound from oregano and thyme, was injected into chicken embryos at day 17.5.
- LPS challenge reduced weight gain and increased spleen weight, but carvacrol did not affect these measures.
- Transcriptomic analysis revealed significant differential gene expression (DEGs) in response to LPS and carvacrol.
- Carvacrol enriched pathways related to T-cell activation, upregulating cytokines and chemokines post-LPS challenge.
- The findings suggest carvacrol modulates immune responses to LPS, with effects lasting up to 14 days post-hatching.