Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort study with causal forest analysis - PubMed
3 hours ago
- #cognitive decline
- #circadian syndrome
- #longitudinal study
- Circadian syndrome (CircS) extends beyond metabolic syndrome to include sleep and mental health.
- The study analyzed 6,218 participants from the China Health and Retirement Longitudinal Study (2011-2018).
- Three cognitive trajectories were identified: 'persistently high' (40.29%), 'persistently moderate' (43.78%), and 'persistently low' (15.93%).
- CircS increased the odds of 'persistently low' global cognitive and episodic memory trajectories.
- A vulnerable subgroup was identified: younger age, mild anemia (Hb ≤95 g/L), and elevated BMI.
- CircS is a significant, modifiable risk factor for adverse cognitive trajectories.
- Screening for CircS could enable early identification and targeted interventions for high-risk individuals.