Revisiting Rosacea Through the Skin-Gut-Brain Axis: A Neuroimmune Perspective - PubMed

3 hours ago

Rosacea is recognized as a complex inflammatory disorder involving the skin-gut-brain axis.
The disorder includes gut microbiota dysbiosis, neuroimmune signaling, and autonomic nervous system dysfunction.
The article proposes rosacea as a neuroimmune disorder with central nervous system involvement.
Key mechanisms include neurogenic inflammation, mast cell activation, and sebaceous gland dysfunction.
Brain-centered mechanisms like central sensitization and autonomic dysregulation are highlighted.
The framework suggests rosacea as a model for studying neuroimmune dysregulation.
Clinical implications include personalized, multidisciplinary therapeutic approaches.

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