Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis - PubMed
4 hours ago
- #ageing biomarkers
- #clonal haematopoiesis
- #inflammageing
- Clonal haematopoiesis (CH) is the presence of acquired mutations in blood cells, linked to ageing and associated with diseases like malignancy and cardiovascular disease.
- CH reflects genomic instability with ageing and may exacerbate features of normal ageing, such as inflammageing and immunosenescence.
- Different forms of CH include mosaic loss of X or Y, autosomal mosaic chromosomal rearrangements, and point mutations or small insertions/deletions.
- The relationship between different forms of CH and other biomarkers of ageing is not well understood, including their co-existence and synergistic effects on clonal expansion.
- Understanding the overlap between CH and other ageing markers is crucial for insights into biological ageing processes and disease mechanisms.
- The article reviews current literature on the intersections of different CH forms, their clinical implications, and how CH enhances understanding of ageing biology.