Study on the anti- pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway - PubMed
4 hours ago
- #Macrophage Polarization
- #Pulmonary Fibrosis
- #Traditional Chinese Medicine
- Renshen Pingfei formula (RSPF) is a traditional Chinese medicine used to treat pulmonary fibrosis (IPF).
- The study investigated RSPF's effects on bleomycin-induced pulmonary fibrosis in mice, focusing on TGF-β/SMAD signaling and M2 macrophage polarization.
- RSPF improved lung fibrosis, reduced collagen deposition, and downregulated fibrosis-related markers like Vimentin, α-SMA, and Collagen I.
- RSPF inhibited M2 macrophage polarization markers (Arg-1, CD206) and suppressed TGF-β1/Smad signaling in both in vivo and in vitro studies.
- The anti-fibrotic mechanism of RSPF involves dual suppression of TGF-β1/Smad signaling and M2 macrophage polarization.