Challenges and advances in drug resistance and tolerance in cancer - PubMed
4 hours ago
- #drug-resistance
- #cancer
- #precision-oncology
- Therapeutic resistance is a major challenge in oncology, especially in oncogene-driven and immune-refractory tumors.
- Mechanisms of resistance include cancer cell plasticity, chromatin reprogramming, and stress-responsive transcriptional networks.
- Tumor microenvironment factors like inflammatory signaling, stromal heterogeneity, and paracrine crosstalk contribute to drug tolerance.
- New insights highlight cancer-associated fibroblast plasticity, immunosuppressive niches, secretory autophagy, and senescence-associated programs.
- Advanced techniques such as single-cell transcriptomics, chromatin profiling, and AI-driven spatial inference reveal vulnerabilities and biomarkers.
- Resistance is a dynamic continuum shaped by evolutionary adaptation and ecological interactions within the tumor microenvironment.
- Emerging strategies focus on disrupting tolerance states, reprogramming immunosuppressive niches, and advancing precision oncology.