Huangqi Guizhi Wuwu Decoction attenuates bleomycin-induced pulmonary fibrosis via modulating TGF-β/Smad and cell-cycle: Integrated transcriptomics, network pharmacology and experimental validation - P
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- #TGF-β/Smad signaling
- #Traditional medicine
- #Pulmonary fibrosis
- Huangqi Guizhi Wuwu Decoction (HGD) attenuates bleomycin-induced pulmonary fibrosis (PF).
- HGD modulates TGF-β/Smad signaling and cell-cycle pathways to exert anti-fibrotic effects.
- The study used in vivo mouse models and in vitro assays with human pulmonary fibroblasts.
- HGD reduced lung injury, collagen deposition, and fibroblast activation.
- It reversed epithelial-mesenchymal transition (EMT) and rebalanced the pulmonary immune microenvironment.
- Transcriptomics and network pharmacology identified key pathways, validated experimentally.
- No overt toxicity was observed at tested doses.
- HGD shows potential as an adjunct therapy for PF.