Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1α - PubMed
3 hours ago
- #nuciferine
- #osteonecrosis
- #ferroptosis
- Nuciferine helps treat steroid-induced osteonecrosis of the femoral head (SONFH) by inhibiting ferroptosis in bone marrow mesenchymal stem cells (BMSCs) via HIF-1α.
- The study screened a natural product library and identified nuciferine as a potent inhibitor of steroid-induced cell death (SiCD).
- Nuciferine suppresses ferroptosis in glucocorticoid-treated BMSCs, promotes osteogenic differentiation, and maintains mitochondrial homeostasis.
- Mechanistically, nuciferine relies on HIF-1α to inhibit ferroptosis and enhance osteogenic differentiation.
- In vivo studies confirmed that nuciferine effectively ameliorates SONFH in rats.
- Nuciferine, being both medicinal and dietary, could be beneficial for patients undergoing glucocorticoid treatment.