Autoimmunity, diet and autophagy - PubMed
4 hours ago
- #autoimmunity
- #immunonutrition
- #autophagy
- Autophagy is a lysosomal recycling pathway linking nutrient availability to immune regulation and cellular quality control.
- Diet influences autoimmune diseases by modulating autophagy, affecting immune tolerance and metabolic inflammation.
- Micronutrient deficiencies (e.g., vitamin D, zinc, selenium, omega-3) impair immune regulation and promote inflammation.
- Overnutrition and Western diets drive chronic inflammation, gut microbiota changes, and autoantibody-related immune activation.
- Autophagy plays key roles in lymphocyte survival, antigen presentation, and cytokine regulation.
- Defective autophagy can lead to improper antigen handling and persistent immune activation.
- Nutritional regulation of autophagy involves pathways like mTORC1, AMPK, and sirtuin 1.
- Fasting and time-restricted eating may enhance autophagy, while high-glycemic diets suppress it.
- A precision immunonutrition framework is proposed for personalized autoimmune disease interventions.